R&D

Developing innovative therapeutics based on next-generation mRNA·LNP platform technology.

mRNA·LNP Platform Technology

🧬 mRNA Platform Stability Simulator

Comparison of RNase resistance: SML's Circular Poly A vs. Conventional Linear Poly A

SML's mRNA Platform (Circular Poly A)
CAP
5' UTR
GOI
3' UTR
POLY(A) 50
ADAPTOR
COMPLEMENTARY
Stability
99%
Circular structure blocks RNase access
VS
Widely Used mRNA Platform (Linear Poly A)
CAP
5' UTR
GOI
3' UTR
POLY(A) 50
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Stability
100%
Exposed 3' end vulnerable to RNase degradation

An innovative mRNA overcoming conventional mRNA limitations

Higher expression levels

Achieves higher expression rates both in vitro and in vivo, enabling greater protein production with lower mRNA quantities.

Enhanced stability

Improved in vivo stability prolongs mRNA persistence in the body, partially addressing its inherent rapid degradation.

Optimized delivery

Proprietary LNP formulation ensures efficient intracellular delivery, maximizing therapeutic efficacy across diverse applications.

SML Biopharm possesses an mRNA platform with optimized UTR and poly(A) tail designed to enhance stability and expression efficiency. While advancing our next-generation mRNA platform and drug pipeline, we independently develop lipid nanoparticles (LNP) for efficient delivery, driving effective R&D and rapid research progress.

Pipeline

Developing innovative therapeutics for various diseases based on mRNA platform technology.

SBP-101

Cancer Vaccine

Immune Response Based Therapeutics

INDICATION Cervical Cancer
Preclinical
Screening
POC
Candidate
Optimization
Preclinical
Clinical
Ph 1
Ph 2
Ph 3
PARTNERS
SBP-102

Cancer Vaccine / mRNA-based bsAb

Immune Response Based Therapeutics

INDICATION HNSCC
POC
Screening
POC
Candidate
Optimization
Preclinical
Clinical
Ph 1
Ph 2
Ph 3
PARTNERS
SBP-801 Gov Grants

Prophylactic Vaccine

Immune Response Based Therapeutics

INDICATION COVID-19
Preclinical
Screening
POC
Candidate
Optimization
Preclinical
Clinical
Ph 1
Ph 2
Ph 3
PARTNERS
KDCA
EuBiologics
SBP-301 Gov Grants

Antibody

In-vivo Protein Expression Therapeutics

INDICATION SFTS (Severe Fever with Thrombocytopenia Syndrome)
Preclinical
Screening
POC
Candidate
Optimization
Preclinical
Clinical
Ph 1
Ph 2
Ph 3
PARTNERS
KDCA
SBP-302

mRNA-based Protein (Novel Target)

In-vivo Protein Expression Therapeutics

INDICATION Sarcopenia
POC
Screening
POC
Candidate
Optimization
Preclinical
Clinical
Ph 1
Ph 2
Ph 3
PARTNERS
SBP-303

mRNA-based bsAb

In-vivo Protein Expression Therapeutics

INDICATION Solid Cancer
POC
Screening
POC
Candidate
Optimization
Preclinical
Clinical
Ph 1
Ph 2
Ph 3
PARTNERS

Development Process

SML Biopharm's drug development process

Discovery

Target discovery and
candidate exploration

Preclinical

Preclinical testing and
efficacy/safety validation

Clinical Trial

Clinical trials
(Phase 1-3)

Regulatory

Regulatory submission
and approval

Commercialization

Commercialization and
market launch

Publications

SML Biopharm's publication portfolio

No publication data available.

Partnership Inquiry

If you are interested in R&D collaboration, please contact us.